Define Preformulation studies. Explain steps involved in Preformulation studies.
[6 marks]How polymorphism and crystallinity influence performance of drug product. Explain in brief methods to identify polymorphism and crystallinity.
[5 marks]Define diluents. Classify Diluents. Write a note on versatility of lactose as diluents in oral solid dosage forms.
[5 marks]Define disintegrating agent. Give examples of commonly used disintegrating agents. Write mechanism of disintegration.
[6 marks]What do you mean by polymer? Write a note on polymers used in different dosage forms with examples.
[5 marks]Write short note on passive diffusion.
[5 marks]Write a note on Prodrug. Discuss Prodrug approaches.
[6 marks]Write a short note on Matrixing and Bracketing study design.
[5 marks]Define bioequivalence. Write a short note on Latin-square cross-over design.
[5 marks]Write a note on factors affecting on stability of pharmaceutical dosage form.
[6 marks]Discuss in detail volume of distribution.
[5 marks]How purity of API and drug degradation are studied in product development?
[5 marks]Discuss Noyes Whitney equation for rate of dissolution. Discuss USP type Iapparatus for dissolution.
[6 marks]Define overages and discuss methods to determine overages.
[5 marks]Discuss remedies to overcome degradation due to hydrolysis and oxidation in pharmaceutical dosage form. Q. 6 (a) Define biopharmaceutics. Enlist various mechanisms of drug transport. Discus active transport in detail.
[6 marks]Draw a well labelled diagram of cell membrane and Discuss Endocytosis.
[5 marks]Define relative and absolute bioavailability. Discuss plasma level time studies for measurement of bioavailability.
[5 marks]Write a short note on “Plasma Protein Binding”
[6 marks]Discuss tissue permeability of drug in distribution.
[5 marks]Write a note on drug clearance.
[5 marks]