Pharmaceutical Chemistry – X (Medicinal Chemistry - III) — Winter 2021

Classify the antianginal drugs with chemical structures.

Explain the SAR of statins.

Write the mechanism of action, synthesis and use of clofibrate.

Classify the oral antidiabetic agents with only drug names. Write the synthesis of metformin.

Describe the mechanism of action and chemistry of insulin.

Classify the drugs used in hyperthyroidism with chemical structures.

Write the chemistry aspects of antihypertensive drugs acting on renin- angiotensin system.

Explain the SAR of 1,4-dihydropyridines as Ca2+ channel blockers.

Write the synthesis of

Any one ACE inhibitor ii) Any one β -blocker1

Classify the antiplatelet agents with chemical structures and mechanism of action.

Define the terms: i) coagulants ii) anticoagulants iii) antiplatelet agents iv) thrombolytics v) plasma expanders

Write a note on plasma expanders.

Discuss the SAR of adrenocorticoids.

Discuss the nomenclature of steroidal hormones.

Write the name, chemical structures and uses of antiestrogens. Q. 6 (a) Write the name, chemical structues, mechanism of action and uses of potassium sparing diuretics.

Write the structure activity relationship of thiazide diuretics.

Define immunomodulators. Write two examples with structure each of immunostimulants and immunosuppressants.

Classify the antiarrhythmic agents with chemical structures.

Define cardiotonic agents. Write the mechanism of action and four examples with structure of cardiac glycosides.

Write the synthesis of flecainide and dobutamine.