Pharmaceutical Engineering II — Summer 2018

Discuss the regulatory requirements of content uniformity as per USP and European Pharmacopoeia.

Enumerate sampling techniques for content uniformity.

Define content uniformity. Enumerate significance of content uniformity.

Enumerate and explain different techniques used for improvement of powder flow.

Define Carr’s Index and Hausner’s ratio with their pharmacopoeial specifications.

Discuss the various factors affecting powder and granule flow.

Define Control chart. Enumerate different types of control charts and discuss any one.

Discuss the elements of Control charts.

Enumerate Control charts for attributes and explain c chart.

Define HME and explain its significance in Pharmaceutical Industry.

Define pellets. Enumerate various factors affecting pellets properties.

What is Eudragit? Explain its role in melt extrusion technology.

Explain the term supercritical fluid, critical temperature and critical pressure with the help of a pressure temperature phase diagram.

Name different techniques involved in micronization employing Supercritical fluid as an antisolvent.

Define and explain pharmaceutical application of inclusion complex. Q. 6 (a) Explain the process of preparing Solid dispersion using supercritical fluid.

Write advantages and disadvantages of RESS process.

Explain applications of supercritical fluid in extraction process.

Write a note on following:

Solid dispersion

Screw extruder

MCC in pelletization