Explain the following terms: i. Teratogenicity ii. Structure activity relationship
[6 marks]Write a short note on local anesthetics.
[5 marks]Describe the pharmacological and physiological role of serotonin.
[5 marks]Explain Dose response relationship and its importance.
[6 marks]Briefly explain various types of animal toxicity studies.
[5 marks]Classify sympathomimetic drugs.
[5 marks]Define biotransformation. Describe enzyme induction and enzyme inhibition with examples.
[6 marks]Explain signal transduction mechanism of G-protein coupled receptors.
[5 marks]Explain in detail about anticholinesterase poisoning and its treatment.
[5 marks]Enumerate routes of drug administration. Give the merits and demerits of intravenous route of drug administration.
[6 marks]Explain drug antagonism. Give difference between competitive and non- competitive antagonism with suitable examples
[5 marks]Write a short note on drugs acting on autonomic ganglia.
[5 marks]Describe in short on the following i. Prostaglandins ii. Histamine
[6 marks]Give difference between non depolarizing agents and depolarizing agents as neuromuscular blockers.
[5 marks]Explain plasma protein binding of drugs and its clinically significant implications with suitable examples. Q. 6 (a) Classify muscarinic and nicotinic receptors with subtypes and explain pharmacological action of Acetylcholine.
[6 marks]Define drug and explain different sources of drugs
[5 marks]Write a short note on bioavailability
[5 marks]Write a short note on neurohumoral transmission.
[6 marks]Explain drug tolerance and dependence.
[5 marks]Write a short note on phases of clinical trials.
[5 marks]