Explain various biological factors to be considered in the design of sustained release dosage forms.
[6 marks]Write a note on Bio erodible controlled drug delivery systems.
[5 marks]Enlist various physicochemical factors to be considered in the design of sustained release dosage forms. Discuss the effect of porosity and tortuosity on release rate of sustained release formulations.
[5 marks]Discuss evaluation of release characteristics for the final dosage form with respect to oral controlled release formulations.
[6 marks]Explain non erodible and erodible ocular control release system.
[5 marks]Write a note on burst effect with respect to controlled release diffusional systems.
[5 marks]Explain in detail about approaches for colon targeted drug delivery system.
[6 marks]Write a note on evaluation of Transdermal drug delivery system.
[5 marks]Explain in brief preparation of microspheres.
[5 marks]Discuss the formulation of parenteral emulsions and suspensions.
[6 marks]Explain various types of osmotic pressure controlled systems with suitable diagram.
[5 marks]Write a note on various classes of matrix tablets with respect to modified drug release dosage forms.
[5 marks]Draw typical plasma concentration time profile curve. Explain Pharmacokinetic and Pharmacodynamics parameters in brief.
[6 marks]Give advantages and disadvantages of compartment modeling. Page 1 of
[2 marks]Adrug has an elimination half life of 8 h and follows first order kinetics. If a single dose 200mg is given to an adult male patient (68 kg) by i.v. bolus injection, calculate the percent of the dose lost in 24h. Q. 6 (a) Define clinical pharmacokinetics. Explain methods for the calculation of creatinine clearance from serum creatinine concentration.
[6 marks]Define drug interaction. Discuss interactions that involve a change in drug absorption from GIT with suitable examples.
[5 marks]Explain dosage adjustment in patients with renal and hepatic failure.
[5 marks]Explain how one can detect nonlinear pharmacokinetics? Explain Michaelis Menten equation for capacity limited process.
[6 marks]Describe One- compartment open model kinetic after iv bolus administration.
[5 marks]Write merits of non- compartmental analysis. Explain AUC & AUMC plots Page 2 of
[2 marks]