Write a short note on the methodology of QSAR studies
[3 marks]What are the key features of molecular mechanics force fields?
[4 marks]Write in detail about discovery of Perampanel starting from competitive inhibitor designing upto clinical phase trials. (Each step in brief)
[7 marks]Give Applications of Molecular Dynamics
[3 marks]Differentiate between the perspectives: Statistical mechanics and Molecular dynamics (In the difference table format only)
[4 marks]Explain about Solvent effects in Molecular Dynamics and give detailed note on Implicit Solvent Models.
[7 marks]Write in detail about Molecular Dynamics at Constant Pressure and temperature, and approaches to understand molecular dynamics in the given condition.
[7 marks]What is meant by drug-likeness?
[3 marks]Briefly describe the use of genetic algorithms in developing QSAR equations.
[4 marks]What is the workflow of virtual screening? Highlight the applications of 3D database searching in this process.
[7 marks]What is the significance of lead optimization in drug discovery?
[3 marks]How are neural networks applied in QSAR studies?
[4 marks]Explain the importance of drug-likeness, compound filtering, and ADMET prediction in successful drug development.
[7 marks]What is the role of bioinformatics in drug design?
[3 marks]Briefly describe the main steps involved in the drug discovery process (Draw only flowchart)
[4 marks]Give a detailed note about rational drug design and high throughput screening as methods of drug designing approaches. Highlight key applications of both approaches along with example. Page 1 of
[2 marks]Explain: protein modelling.
[3 marks]How does bioinformatics assist in modelling target-small molecule interactions?
[4 marks]Compare and contrast Structure-Based Drug Design (SBDD) and Ligand-Based Drug Design (LBDD) with suitable examples.
[7 marks]Give a short-note on the pharmacokinetic properties of Perampanel- an anti-epileptic drug
[3 marks]Differentiate between electrostatic interactions and van der Waals interactions in molecular mechanics.
[4 marks]Explain the strategy for target identification and validation in drug discovery. State how you identify and validate a particular target using different methods.
[7 marks]Give a short-note on the clinical trials of Perampanel- an anti-epileptic drug
[3 marks]Explain the concept of energy minimization and its application in molecular modelling.
[4 marks]Explain the strategy for Modeling of Target-Small Molecule Interactions along with the methods and applications in detail. Page 2 of
[2 marks]