Pharmaceutical Organic Chemistry II — Winter 2023

What do you mean by electrophilic aromatic substitution reaction? Write in detail about Friedel crafts alkylation reaction with its mechanism. Write its limitations.

Write about nitration reaction of benzene with its mechanism.

Derive structure of benzene by analytical, synthetic and other evidences.

Write about Haworth synthesis of Naphthalene and Anthracene with name of all intermediates. (Discussion for the reactions are not necessary)

Write three reactions of naphthalene and anthracene.

Explain in detail about Huckele’s rule of aromaticity with suitable examples.

Write conversions (Number of steps as per student’s choice):

. Phenol from Aniline ii). p-Nitrophenol from Chlorobenzene

Write a detailed note on effects of substituents on acidity of aromatic carboxylic acids.

Write a detailed note on effects of substituents on basicity of aromatic amines.

Make a detailed note on following reactions:

. Dow process ii). Riemer-Tiemann reaction

Write qualitative tests of phenol.

i). Write in detail about synthesis of phenol by cumene process (Discussion is not necessary). ii). Write Fries rearrangement reaction (Discussion is not necessary).

Write diazotization reaction. Give synthetic uses of aryl diazonium salts.

Write three preparations and three reactions of carboxylic acids.

Write structure and uses of:

. Diphenylmethane ii). Phenol iii). Cresol iv). DDT v). Saccharin Q. 6 (a) Write about significance and principle involved in:

. RM value ii). Saponification value iii). Iodine value

Make a detailed note on reactions of fatty acids.

Explain in detail about Rancidity.

What do you mean by cycloalkanes? Give detail note on Bayer’s strain theory of cycloalkanes.

Write reactions of cyclopropane and cyclobutane.

Write in detail about Sachse Mohr’s theory of cycloalkane.