Explain the terms delayed release, extended release and controlled release. Discuss merits of controlled release drug delivery systems.
[6 marks]Describe the physicochemical properties of drug molecule required for controlled drug delivery system.
[5 marks]Classify controlled release drug delivery systems. Describe matrix systems.
[5 marks]What is transdermal drug delivery system (TDDS)? Describe matrix formulation approach for TDDS.
[6 marks]Describe the factors affecting permeation of drug through barrier of skin.
[5 marks]What is mucosal drug delivery? Describe theories of muco-adhesion.
[5 marks]Differentiate between liposome and niosome. Describe their therapeutic application.
[6 marks]Classify various methods for preparation of liposomes. Explain remote loading method in detail.
[5 marks]What are nanoparticles? Discuss evaluation of nanoparticles.
[5 marks]What are monoclonal antibodies? Describe their advantages, limitations and applications.
[6 marks]Name the intraocular barriers to drug permeation. Describe methods to overcome intra ocular barriers of the eye.
[5 marks]What is ophthalmic in situ gel? Describe different type of ocular inserts.
[5 marks]Enlist methods of microencapsulation. Discuss spray drying and spray congealing method.
[6 marks]Differentiate between microsphere and microcapsule. Discuss advantages and limitations of microencapsulation.
[5 marks]What are intrauterine devices (IUDs)? Discuss hormone releasing IUDs. Q. 6 (a) What is implantable drug delivery? Describe Higuchi Leeper pump.
[6 marks]What are osmotic tablets? Discuss multiple chamber osmotic pumps with diagram.
[5 marks]Explain glass transition temperature of polymer. Describe smart polymers with examples.
[5 marks]Explain gastro-retentive drug delivery system (GRDDS). Describe advantages and limitations of GRDDS.
[6 marks]Enlist approaches for gastric retention. Discuss high density and raft forming approaches.
[5 marks]Compare and contrast metered dose inhalers and dry powder inhalers for drug delivery.
[5 marks]