Give the historical overview of Bioinformatics.
[3 marks]What is consensus sequence?
[4 marks]Briefly explain the role of NCBI. Further, discuss MMDB.
[7 marks]Enlist the tools of Entrez.
[3 marks]Write with an example: global alignment.
[4 marks]Discuss the importance of molecular biology in understanding bioinformatics.
[7 marks]For what attributes, do the phylogenetic analysis help?
[7 marks]What is cladistics and systemics?
[3 marks]How is the score calculated for BLAST and transition-transversion matrices?
[4 marks]Explain the terms: target identification and validation, lead molecule identification and optimization.
[7 marks]Describe Hidden Markov Model.
[3 marks]Narrate the major features of PDB.
[4 marks]Give the importance of multiple sequence alignment.
[7 marks]Write the steps of Chau-Fasman method for secondary structure prediction.
[3 marks]What is DNA microarray?
[4 marks]Make a clear list of applications of Bioinformatics and briefly important of all.
[7 marks]Make a list of all the tools for gene prediction.
[3 marks]Discuss maximum parsimony method representing phylogeny.
[4 marks]What are the major tools or techniques in proteomics? Explain any two of them.
[7 marks]“Protein structure is related with its function’. Discuss briefly.
[3 marks]Write the steps for GOR IV method.
[4 marks]What is Single nucleotide polymorphism? Explain.
[7 marks]Define: Progressive alignment.
[3 marks]What is clinical trial? What are its phases?
[4 marks]Explain the types of proteomics studies, based on their characteristics.
[7 marks]