How is the preformulation study of IR tablet dosage form of an API belonging to BCS Class II is carried out?
[6 marks]Summarize applications of free-flowing powders in pharmacy and discuss methods for their characterization.
[5 marks]Write a note on polymorphism aspect of an API in relation to preformulation study
[5 marks]Explain the role of polymers in pharmaceutical drug delivery.
[6 marks]Which different categories of pharmaceutical adjuvants are used as disintegrants? Discuss any one of them in detail.
[5 marks]Write a short note on natural gums used as pharmaceutical necessities.
[5 marks]Define: (a) Reaction rate. (b) Overages. (c) Half-life
[6 marks]How is an order of reaction determined? Discuss different approaches utilized to determine it.
[5 marks]Enumerate different factors affecting the stability of a dosage form and discuss each in brief.
[5 marks]Differentiate between Active transport and Passive transport process for drug absorption.
[6 marks]Draw a schematic diagram depicting absorption of drugs from orally administered solid dosage form and explain the steps involved in it.
[5 marks]Which are the different theories of drug dissolution? Write in detail regarding Film theory of dissolution.
[5 marks]Define the following — Therapeutic equivalence, Pharmaceutical equivalence and Bioequivalence.
[6 marks]Enlist the elements of a bioequivalence study protocol.
[5 marks]Give an overview of various excretory routes, mechanism of drug transport and nature of drug excreted involved in drug excretion process. Q. 6 (a) Tabulate different types of compendial dissolution apparatus according to USP and their applications and discuss dissolution methodology used for IR drug product based on BCS
[6 marks]What is the importance of similarity factor f in dissolution profile comparison?2
[5 marks]Write a short note on BDDCS.
[5 marks]Enlist different approaches for increasing and decreasing the solubility of drug. Discuss any one from each in detail.
[6 marks]Define apparent volume of distribution. Why cannot the volume of distribution of a drug have a true physiologic meaning?
[5 marks]Why protein binding of drugs is important to study in field of biopharmaceutics?
[5 marks]