Define Preformulation? Explain the physicochemical propertie related to solubility analysis in Preformulation.
[6 marks]Enumerate the chemical properties affecting preformulation studies in designing a dosage form and discuss any one in details giving suitable illustrations.
[5 marks]What in the meaning of prodrugs. Give its application in formulation.
[5 marks]Describe the ideal properties of a preservative.
[6 marks]Define biodegradable polymers? Explain its mechanism of biodegradation with suitable example
[5 marks]Enlist the cellulosic derivative polymers. Give detail about Hypromellose. Q .3 (a) Write a short note on matrixing and brac keting study design 0
[6 marks]Define Half life, Self life and Overage. Discus about international climatic zones as per ICH guideline.
[5 marks]Describe Overages with methods of calculating it. Q .4 (a) Enlist factors affecting gastro intestinal a bsorption. Discus in detial effact of gastric 0 empting time on drug absorption.
[6 marks]What are the physiologic barriers to distribution of drugs?
[5 marks]Discuss the absorption of drugs from non-oral extravascular routes. Q .5 (a)Explain bioavailability. Discuss its object ive. Explain plasma level time studies for 0 measurement of bioavailability.
[6 marks]Define bioequivalence. Write a note on Latin square cross over design.
[5 marks]How the bioavailability of drug can be improved? Q. 6 0
[6 marks]Enlist the theories of dissolution. Explain in detail Noyes Whitney’s Theory
[ marks]Describe In-vitro - In-vivo correlations.
[5 marks]Explain Accelerated stability study and explain method for calculation of Shelf life. Q .7 (a) Explain BCS. Give its objective. Write f actors affecting drug dissolution with 0 respect to test apparatus.
[6 marks]Enlist the dissolution apparatus. Discus Apparatus III, IV and Vwith labeled diagram.
[5 marks]Define Dissolution profile. Write a note on similarity factor and dissimilarity factor.
[5 marks]