What is ligand? Explain the preparation of ligand library for CADD.
[6 marks]Explain in detail about target based CADD.
[5 marks]Differentiate between SBDD and LBDD.
[5 marks]Explain various technique for detection and characterization of binding site.
[6 marks]Which genetic algorithm are used for protein-ligand docking?
[5 marks]Explain various scoring function for evaluation of protein ligand interaction.
[5 marks]Write a note on virtual HTS.
[6 marks]Explain virtual screening using pharmacophore modelling.
[5 marks]Write a note on high resolution docking.
[5 marks]What are physicochemical properties? Explain octanol/water partition.
[6 marks]Explain about 4-Dand 5-D QSAR.
[5 marks]Write a note on pharmacophore mapping.
[5 marks]Explain methods for optimization of drug metabolism.
[6 marks]How prediction of human ether-a-go-go related gene binding done?
[5 marks]Describe various software and their application for toxicity prediction. Q. 6 (a) Explain binary molecular finger prints.
[6 marks]Describe about 3-Ddescriptor used for molecular properties.
[5 marks]What is lead compound? How it can be optimized? Q. 7 (a) Explain how to represent small molecules as SMILES.
[6 marks]Write a note on Monte Carlo simulation.
[5 marks]Write a note on 2-Ddescriptors
[5 marks]