Define ligand based CADD. Enumerate its features and explain binary molecular fingerprints in detail.
[6 marks]Write a note on dynamic pharmacophore model.
[5 marks]What are docking? Describe various docking methods.
[5 marks]Explain how comparative modeling method used for preparation of a target structure for SBDD.
[6 marks]Write a note on knowledge based scoring function and consensus scoring function.
[5 marks]Explain genetic algorithms in SBDD
[5 marks]Write a note on multidimensional QSAR.
[6 marks]Discuss on Toxicity Prediction software packages.
[5 marks]Define force field and describe various methods for energy minimization.
[5 marks]Describe application of QSAR in lingand based CADD.
[6 marks]Write in detail about COMFA and COMSIA methods of QSAR.
[5 marks]Explain about linear regression methods.
[5 marks]Write a note on pharmacophore algorithms and software packages.
[6 marks]Explain how ligand libraries were prepared for CADD?
[5 marks]Describe about the target data bases for computer aided drug design in detail. Q. 6 (a) Enumerate different approaches for binding site detection and characterization in SBDD and explain any one in detail.
[6 marks]Write down prediction of ADME in detail.
[5 marks]Explain about 3D description of molecular configuration and conformation.
[5 marks]Explain in detail about SBVS.
[6 marks]Write a note on high resolution docking.
[5 marks]Write a note on importance of various drug design approaches in drug discovery.
[5 marks]