Physical Pharmaceutics I — Summer 2024

Define interfacial tension. Discuss in detail DuNouy Ring Method.

Write a note on Hydrophilic-lipophilic balance (HLB).

Explain the formation of electric double layer with a neat labelled diagram.

Explain Henry’s law and factors affecting for solubility of gases in liquids.

Define solubility. Describe the solute - solvent interactions that influence the solubility of drugs in liquids.

Define Raoult’s law. What is the significance of positive and negative deviation from Raoult’s law on solubility?

State & explain Nernst’s distribution law with its limitation and application.

Enlist various methods for transport of drug across GIT. Discuss in detail passive diffusion.

Define adsorption isotherm. State Freundlich adsorption equation and plot.

Write a brief note on polymorphism with its application.

Define ideal gases and real gases. Explain ideal gas equation with its application.

Define the followings: Boiling point, Critical temperature, Isomorphism, Phase, Critical solution temperature.

Explain the principle and method of Claude’s process for liquefaction of gases.

Explain with the help of suitable example how drug protein binding influences the pharmacokinetics, pharmacodynamics and drug action in various ways.

Write a detail note on inclusion complexes. Q. 6 (a) Define and classify the complexation. Write in detail about “chelates”.

Write a note on spreading coefficient.

Discuss in detail common ion effect and the buffer equation for a weak acid and its salt.

Describe Sorensen’s pH scale. Write applications of buffers in pharmacy.

Enlist various methods to adjust tonicity. Describe freezing point depression method for adjusting the tonicity of a solution

Write a short note on “Buffer Capacity”