Classify the β (beta)-adrenergic receptor blocking drugs. Justify the use of β (beta)-adrenergic receptor blocking drugs in cardiovascular disease.
[6 marks]Classify the neuroleptic drugs. Discuss the adverse effects and therapeutic uses of neuroleptic drugs.
[5 marks]Write in detail about the nature and source of the drugs.
[5 marks]Explain the molecular structure and signal transduction pathway of G-protein- coupled receptor.
[6 marks]Classify the drug used in the treatment of Parkinson’s disease. Justify, "The combination of levodopa and cabidopa is a rational fixed dose combination".
[5 marks]Classify the antiepileptic drugs. Explain the mechanism of action and adverse effects of phenytoin.
[5 marks]Explain the ethanol toxicity. Justify, “Disulfiram use to treat alcohol dependence”.
[6 marks]What is a dose-response relationship? Describe the application of a graded dose- response curve.
[5 marks]Write the difference between sedative and hypnotic agents. Justify, “Benzodiazepines are preferred over barbiturates”
[5 marks]Explain the following terms with examples: a) Drug dependence; b) Tachyphylaxis;
[6 marks]Drug idiosyncrasy
[ marks]Define anaesthesia. Discuss in detail the preanaesthetic medication.
[5 marks]Enlist different steps of the drug discovery and development process. Explain the preclinical evaluation phase in detail.
[5 marks]Explain the physicochemical factors affecting drug absorption.
[6 marks]Classify parasympatholytic drugs. Write the pharmacological actions of atropine.
[5 marks]Enlist various routes of administration. Write merits and demerits of the parenteral route of administration. Q. 6 (a) Define antagonism. Explain in detail pharmacological antagonism.
[6 marks]Classify antidepressant drugs. Write mechanism of action and adverse effects of tricyclic antidepressants.
[5 marks]Define ADR. Explain the types of adverse drug reactions with examples.
[5 marks]Classify anticholinesterase drugs. Write pharmacological action and poisoning of anticholinesterase drugs.
[6 marks]Explain the pharmacokinetic drug-drug interaction with examples.
[5 marks]Write mechanism of action and adverse effects of local anaesthetic agents.
[5 marks]