Explain the terms delayed release, extended release and controlled release. Discuss advantages of controlled release drug delivery systems.
[6 marks]Classify controlled release drug delivery systems. Describe matrix systems.
[5 marks]Describe the physicochemical properties of drug molecule required for controlled drug delivery system.
[5 marks]Explain glass transition temperature of polymer. Describe smart polymers with examples.
[6 marks]Differentiate between microsphere and microcapsule. Discuss advantages and limitations of microencapsulation.
[5 marks]Enlist methods of microencapsulation. Describe spray drying-spray congealing method.
[5 marks]What is mucosal drug delivery? Describe theories of muco/bio-adhesion.
[6 marks]Discuss formulation approaches for buccal drug delivery systems.
[5 marks]What is transdermal drug delivery system (TDDS)? Describe matrix formulation approach for TDDS.
[5 marks]What is implantable drug delivery? Describe Alzet osmotic pump with diagram.
[6 marks]Describe the factors affecting permeation of drug through barrier of skin.
[5 marks]What is targeted drug delivery? Describe passive and active targeting in detail.
[5 marks]Explain gastro-retentive drug delivery system (GRDDS). Describe advantages and limitations of GRDDS.
[6 marks]Enlist approaches for gastric retention. Discuss high density and raft forming approaches.
[5 marks]What are nanoparticles? Describe pharmaceutical applications of nanoparticles. Q. 6 (a) Compare and contrast metered dose inhalers and dry powder inhalers for drug delivery.
[6 marks]Explain first, second and third- order targeting. Discuss advantages and disadvantages of liposomes as a drug carrier.
[5 marks]Explain monoclonal antibodies. Describe their advantages, limitations and applications.
[5 marks]Name the intraocular barriers to drug permeation. Describe methods to overcome intra ocular barriers of the eye.
[6 marks]What are intrauterine devices (IUDs)? Discuss hormone releasing IUDs.
[5 marks]What is ophthalmic in situ gel? Describe different type of ocular inserts. -----------------------------------------------***************-------------------------------------------
[5 marks]