Explain the principle and instrumentation of Super Fluid Chromatography.
[6 marks]Describe Flame Ionization Detector.
[5 marks]Explain the principle and applications of RIA. Explain Enzyme immuno assay- ELISA.
[5 marks]Explain different types of IPR and write the steps for patent filing.
[6 marks]Write a note on GLP.
[5 marks]What is analytical method validation and explain various validation parameters as per ICH guideline.
[5 marks]Explain Bragg’s law equation for diffraction of X-rays by crystals and list applications of X-ray diffraction.
[6 marks]Explain technique of Affinity chromatography.
[5 marks]Explain principle and applications of ion exchange chromatography.
[5 marks]Explain hyphenation technique: LC-MS.
[6 marks]Explain various stationary phases used in gas chromatography.
[5 marks]Write a note on mobile phase used in HPLC.
[5 marks]Differentiate: 1. Reverse and Normal phase chromatography 2. HPTLC and HPLC 3. Capillary and Open tubular column
[6 marks]Write a note on Turbidimetry.
[5 marks]Write a brief note on Size exclusion chromatography. Q. 6 (a) List ideal requirements of detector for HPLC and explain UV-Visible detector in HPLC.
[6 marks]What are the various steps for chromatographic development in HPTLC.
[5 marks]Explain isotope dilution analysis and liquid scintillation counter.
[5 marks]Differentiate: HPLC and GC.
[6 marks]Give an overview of GC-MS.
[5 marks]Explain objective and advantages of ISO 9001 standards. Also explain quality management system in pharmaceutical industry.
[5 marks]