Define preformulation. Write a note on physicochemical properties related to solubility study in preformulation.
[6 marks]Explain effect of pKa and pH on absorption parameter.
[5 marks]Enumerate the drug degradation pathways and discuss Hydrolysis in detail.
[5 marks]Explain world climatic zones as per ICH guidelines.
[6 marks]Discuss the effect of containers and closures on stability of pharmaceuticals.
[5 marks]What do you understand by prodrug? Give its applications for improving stability of drug.
[5 marks]Enlist factors affecting gastro intestinal absorption. Discus in detail effect of gastric empting time on drug absorption.
[6 marks]Write a short note on kinetics of protein-drug binding
[5 marks]Discuss Matrixing and Bracketing Techniques
[5 marks]What do you understand by first pass metabolism? How would you avoid it?
[6 marks]Write a note on similarity factor and dissimilarity factor.
[5 marks]Enlist the theories of dissolution. Explain in detail Film Theory.
[5 marks]“Hydrophylicity and lipophylicity property of a drug decide its absorption” Comment with justification.
[6 marks]Write a note on pharmaceutical excipients used as tablet binder and granulating agent.
[5 marks]Explain various methods used for enhancement of bioavailability. Q. 6 (a) Discuss the regulatory requirements for conduction of bio-equivalence studies.
[6 marks]Write a note on volume of distribution.
[5 marks]Explain renal clearance.
[5 marks]Classify the polymers. Discuss in brief about polymer properties.
[6 marks]Write a note on Biodegradable polymers.
[5 marks]Enlist the cellulosic derivative polymers and discuss its Phthalate derivatives.
[5 marks]