Define Pre-Formulation study. Enlist techniques used in it. Describe any one of them to ascertain Drug-Excipient Compatibility.
[6 marks]Explain the influence of chemical properties of drugs on formulation and stability of the products.
[5 marks]Explain: 1) Overages 2) Climatic Zones.
[5 marks]Discuss Effect of physical properties of drug like physical form, particle size and shape on formulation, stability and bioavailability.
[6 marks]Enlist additives used in tablet dosages form. Discuss the anti frictional agents.
[5 marks]Write a note on prodrugs.
[5 marks]Classify additives used in pharmaceutical formulations. Describe in detail about suspending agents.
[6 marks]Discuss stability testing of new drug substances and products as per ICH Guideline.
[5 marks]Explain the characteristics of Active transport process. Write their application in the development of formulation and administration of drugs.
[5 marks]Discuss the factors affecting stability of pharmaceutical formulation.
[6 marks]Describe Matrixing and bracketing in stability study.
[5 marks]What is IVIVC? Describe In-vitro - In-vivo correlations levels.
[5 marks]Enumerate the factors affecting drug absorption from GIT. Discuss the effect of gastric emptying, drug pKa and GI pH on drug absorption.
[6 marks]Discuss plasma protein drug binding.
[5 marks]Enumerate the drug transport mechanisms. Discuss passive diffusion in detail. Q. 6 (a) Write a note on similarity factor and dissimilarity factor.
[6 marks]Classify the methods for bioavailability measurement. Discuss the method based on plasma data.
[5 marks]Define absolute and relative bioavailability. Describe Latin Square cross over design for bioequivalence study.
[5 marks]What is BCS? Classify and give the significance of this system
[6 marks]Discuss the factors affecting drug dissolution.
[5 marks]Explain USP dissolution apparatus III, IV and Vwith diagram.
[5 marks]