Explain preformulation studies. What is partition coefficient? What is its significance in preformulation?
[6 marks]What is photolysis? Describe the means to prevent photodegredation of drugs.
[5 marks]What is prodrug? Describe the prodrug design approach for drug targeting with examples.
[5 marks]Enumerate additives used in tablets. Describe various mechanisms of disintegration.
[6 marks]What are polymers? Describe in details about biodegradable polymers.
[5 marks]Describe the polymers used for achieving modified drug release with examples.
[5 marks]What is formulation stability? Discuss the different climatic zones for stability testing.
[6 marks]Describe matrixing and bracketing in stability study.
[5 marks]What are overages? In which formulations are they allowed? How are they calculated?
[5 marks]What is drug transport? Describe active transport of drug through biomembrane.
[6 marks]Describe the pH Partition theory for drug absorption.
[5 marks]What is protein drug binding? Describe displacement drug interactions in protein binding.
[5 marks]What is suprabioavilability? Describe AUC, Cmax and Tmax as bioavailability measures.
[6 marks]Describe Latin Square cross over design for bioequivalence study.
[5 marks]Discuss the regulatory requirements for conduction of bioequivalence studies. Q. 6 (a) What is BCS? What is its significance in dosage form design?
[6 marks]What is biorelevant dissolution media? Name the USP dissolution apparatus with the use.
[5 marks]What is dissolution efficiency? Describe dissolution data comparison based on f and f .12
[5 marks]What is sink condition? Describe methods to achieve in vitro sink condition.
[6 marks]What is BBB? Describe approaches used to target polar drugs to brain.
[5 marks]What is importance of protein drug binding? Discuss tissue binding of drugs.
[5 marks]