Explain the influence of chemical properties of drugs on formulation and stability of the products.
[6 marks]Discuss theoretical aspects for determining solubility and permeability of the drug and its assessment.
[5 marks]Enlist additives used in tablet dosages form. Discuss the anti frictional agents.
[5 marks]Write a note on prodrugs.
[6 marks]Effect of physical properties of drug like physical form, particle size and shape on formulation, stability and bioavailability.
[5 marks]Write a note on Biodegradable polymers.
[5 marks]Explain the role of biopharmaceutics in formulation development.
[6 marks]Write a note on polymers used for achieving modified drug release.
[5 marks]Explain various types of equivalence. How Latin square cross over design works?
[5 marks]Write a note on factors affecting drug absorption.
[6 marks]Discuss the regulatory requirements for conduction of bio-equivalence studies.
[5 marks]Volunteer selection for bioavailability studies is a critical issue. Discuss the statement with examples.
[5 marks]Enumerate the drug transport mechanisms. Discuss passive diffusion in detail.
[6 marks]What is BCS classification? How does it affect development of dosage form?
[5 marks]How temperature degradation study is applied to pharmaceutical formulations? Derive an equation for half-life and method to establish expiry date and overages in formulations. Q. 6 (a) Write in detail about facilitated diffusion and pinocytosis.
[6 marks]Explain USP dissolution apparatus III, IV and Vwith diagram.
[5 marks]Discuss the factors affecting stability of pharmaceutical formulation.
[5 marks]What is the importance of protein binding of drugs? Describe tissue binding of drugs in detail.
[6 marks]Storage conditions for stability testing as per ICH guidelines.
[5 marks]What is matrixing and bracketing?
[5 marks]