Discuss pH –Partition hypothesis briefly with suitable examples. Enumerate the assumptions of this hypothesis.
[6 marks]Explain the role of polymorphism and crystallinity in preformulation. Enlist the methods to identify polymorphism.
[5 marks]Discuss theoretical aspects for determining solubility and permeability of the drug and its assessment.
[5 marks]Enumerate the drug degradation pathways and discuss Hydrolysis in detail.
[6 marks]Write a note on semi-synthetic cellulosic derivatives as pharmaceutical excipients.
[5 marks]Define bioequivalence. Write a short note on Latin-square cross-over design.
[5 marks]Discuss the physiological factors influencing the drug absorption.
[6 marks]Describe the influence of BBB and CSF barriers on distribution of drugs.
[5 marks]Write in detail about facilitated diffusion.
[5 marks]Discuss the factors affecting stability of pharmaceutical formulation.
[6 marks]Explain accelerated stability study as per ICH guidelines.
[5 marks]Discuss the effect of containers and closures on stability of pharmaceuticals.
[5 marks]What are similarity factor and dissimilarity factor, how are they calculated and give their significance.
[6 marks]Enlist various methods for measurement of bioavailability. Discuss any one in detail.
[5 marks]Discuss the regulatory requirements for conduction of bio-equivalence studies. Q. 6 (a) Explain USP dissolution apparatus III, IV and Vwith diagram.
[6 marks]Write a note on Biodegradable polymers.
[5 marks]Discuss in detail volume of distribution.
[5 marks]What is BCS classification? How does it affect development of dosage form?
[6 marks]What is the importance of protein binding of drugs? Describe tissue binding of drugs in detail.
[5 marks]Write a note on drug clearance.
[5 marks]