Give the difference between sustained and controlled drug delivery system. Describe the evaluation of oral controlled drug delivery system.
[6 marks]Describe the advantage, disadvantage and limitation of sustained release formulation.
[5 marks]Describe loading and maintenance dose in controlled release formulation with equations.
[5 marks]Explain Pharmacokinetic. Explain typical plasma level time curve affect single oral dose.
[6 marks]Describe Wegner-Nelson method for determination of adsorption rate constant.
[5 marks]Explain in detail compartmental and non compartmental approach.
[5 marks]Mention the method of evaluation of microspheres in detail.
[6 marks]Classify the polymer used in preparation of matrix tablet. Give two name of each class.
[5 marks]What is Nano particle. Give any one method in detail for preparation of Nano particle.
[5 marks]Explain renal clearence. Describe graphical method for determination of renal clearance.
[6 marks]Write a note on osmotic ocular inserts. Explain parts of ocular inserts.
[5 marks]Explain non linear pharmacokinetic using michaeles menten equation.
[5 marks]Describe the ideal requirements for Sustained release formulation. Explain lag time, burst effect and reservoir system with respect to controlled release formulation.
[6 marks]Explain Pharmacokinetic and Pharmacodynamic parameters to be consider for designing modified drug delivery system.
[5 marks]Write a note on Hydrogel. Q. 6 (a) Discuss Mechanism of release of drug from controlled release drug delivery system.
[6 marks]Explain the Pharmaceutical approach to develop colonic drug delivery system in brief.
[5 marks]Explain Volume of distribution and distribution coefficient.
[5 marks]What criteria are necessary for selection of drug as a candidate for controlled release formulation. Explain each in brief.
[6 marks]Define clinical pharmacokinetic and explain dosage adjustment in patient with renal failure.
[5 marks]Discuss the formulation of parenteral emulsion and suspension.
[5 marks]