Discuss in brief the Hixon and Crowell’s cube root dissolution equation for controlled release dosage forms.
[6 marks]Explain biological and physicochemical factors, which are responsible for designing oral sustained release drug delivery system.
[5 marks]Explain loading dose and maintenance dose used in controlled release formulation.
[5 marks]Explain lag time, burst effect and reservoir systems with respect to control release formulations.
[6 marks]Explain apparent volume of distribution. State its significance.
[5 marks]Describe preparation and evaluation of parenteral suspension.
[5 marks]What is non-linear pharmacokinetic? Describe the equation that governs the non- linear Pharmacokinetics.
[6 marks]Write a note on osmotic ocular inserts. Mention the components of each part.
[5 marks]Give an account of approaches for designing of gastro retentive dosage forms.
[5 marks]Discuss one compartment open model - i.v. infusion model and discuss the effect of loading i.v. injection dose. Describe the derivation of various pharmacokinetic parameters for the model.
[6 marks]Classify liposomes? Why are considered versatile carriers for parenteral drug delivery.
[5 marks]Explain the significance of renal clearance and dosage regimen.
[5 marks]What properties are required for the drug to be a candidate for transdermal drug deliverysystem? Explain formulation of transdermal drug delivery system.
[6 marks]Define clinical pharmacokinetics and explain dosage adjustment in patients with renal failure.
[5 marks]Write a note on Hydrogel.
[5 marks]Define ‘Drug interaction’. Discuss the factors that contribute to drug interaction. Give suitable examples.
[6 marks]Write a note on: Wagner-Nelson method used to estimate absorption rate constant (ka)
[5 marks]Define clearance, total body clearance and organ clearance. What is extraction ratio?
[5 marks]Explain pharmacokinetic and pharmacodynamics parameters, which are considered in design of, modified drug delivery systems?
[6 marks]Enlist different approaches for formulation of colon targeted drug delivery system and explain any one of them.
[5 marks]Write a note on evaluation parameters of microsphere.
[5 marks]