Process Technology of Drugs and Intermediates and — Winter 2022

Define the term: Hydrogel nanoparticle.

Write a brief note on Marckwald principle & Reciprocal resolutions with example.

List out the factors for choosing solvents. Describe any six of them.

Write applications of nanotechnology in pharmaceutical field.

What are super critical solvents?What are the advantages & disadvantages of super critical solvents?

List out the factors to be considered while choosing a filtration equipment. Describe any two filtration equipment with neatly labeled diagrams.

Describe the characterization tests for nanoparticles.

What are Gold nanoparticles? What are the applications of Gold nanoparticles?

Discuss the steps to be taken for optimizing the mesylation of Propargylic alcohol

Explain spray drying method with neat labeled diagram for nanoparticles formulation.

Draw a neatly labeled structure of micelle and briefly explain.

Describe any one method of resolution of racemates by direct crystallization with suitable examples.

What are micelles? Write its applications & advantages in pharmaceutical dug delivery.

Explain super critical fluid technology.

What is a “reagent”? Discuss the properties to be considered while selecting a reagent.

Explain the Use of Calorimetry in addressing reaction safety. Illustrate with examples.

Write a short note on SMB (simulated moving bed chromatography).

Define chiral auxiliary. Describe the use of chiral auxiliary with a schematic diagram. Write one example of the use of chiral auxiliary.1

Discuss the steps to be taken for the optimization of process. Illustrate with example.

Differentiate between nanoparticles & micro particles.

Write a note on Phase transfer catalyst. What are the factors to be considered while choosing a Phase Transfer Catalyst (PTC) & how selectivity in PTC can be achieved?

Explain the quality control tests for nanoparticles.

Define Dendrimers and give its applications.

Explain the selection criteria for resolving agents.

Write a note on Top down and Bottom up technology for nanoparticle generation.