Biopharmaceutics & Pharmacokinetics — Winter 2022

Define drug absorption. Discuss the various factors influencing GI absorption of a drug.

Explain briefly about different mechanism of drug Absorption.

What are the physiological barriers of distribution? Add a note on BBB.

Explain briefly Michaelis – Menton method for estimation of Km and Vmax.

Explain Wagner Nelson method for computing absorption rate constant

Write a note on methods to enhance the bioavailability through enhancement of dissolution rate.

Explain briefly the following terms:  Mean residence time  Hepatic clearance  Renal clearance.

Write note on Apparent volume of distribution and its significance.

Write note on Catenary model.

Discuss causes of non-linearity with example.

How to determine bio-availability through urinary extraction studies?

Discuss Latin square design in Bioequivalent study.

Define Bioavailability. Explain various methods used for determination of Bioavailability.

What are the factors affecting drug dissolution and dissolution rate. Explain them.

Differentiate active transport and passive diffusion. Q. 6 (a) Explain briefly the two compartmental open model extra vascular administrations.

Write the merits and demerits of non compartmental pharmacokinetics.

Describe open one compartment model IV bolus administration.

Discuss protocol bioequivalence study.

Write note on Approaches for dosage regimen.

Write note on Significance of protein binding.