Enlist various mechanism of drug transport. Write a detailed note on active transport process.
[6 marks]Discuss various factors affecting drug absorption through GIT.
[4 marks]Discuss various barriers of Drug Distribution.
[4 marks]Explain Catenary and Mammillary compartment models in detail.
[6 marks]Define: 1) Therapeutic window 2) Onset of action 3) Minimum effective concentration 4) Maximum safe concentration
[4 marks]Write a note on Physiological Pharmacokinetic model.
[4 marks]Explain the one-compartment open model of pharmacokinetics. How does this model apply to intravenous bolus administration?
[6 marks]Define clearance and write about renal clearance in detail.
[4 marks]Write a note on volume of distribution.
[4 marks]Explain the two-compartment open model with examples of drug administration routes.
[6 marks]Describe the method of residuals for determination of absorption rate constant
[4 marks]Write note on Loo Riegelman Method.
[4 marks]Discuss the effect of size of drug dose and frequency of administration on design of a dosage regimen.
[6 marks]Write note on statistical moment theory.
[4 marks]How mean residence time is estimated for one compartment?
[4 marks]Derive Michalis menten equation and give its limitation.
[6 marks]Write note on causes of non-linearity.
[4 marks]What is IVIVC? Write a note on Levels of IVIVC.
[4 marks]Explain various methods used for enhancement of bioavailability.
[6 marks]Explain Wagner nelson method in detail.
[4 marks]Define bioequivalence. Explain Latin crossover design in BE studies.
[4 marks]