Define clearance and write about renal clearance in detail.
[6 marks]Describe the Pharmaceutical factors affecting drug absorption from GI tract.
[4 marks]Write a short note on kinetics of protein-drug binding.
[4 marks]What is IVIVC? Write a note on Levels of IVIVC.
[6 marks]Explain various methods used for enhancement of bioavailability.
[4 marks]Explain Wagner nelson method in detail.
[4 marks]Define bioequivalence. Explain Latin crossover design in BE studies.
[6 marks]Explain the dissolution apparatus type Iand type II as per USP.
[4 marks]Differentiate absolute and relative bioavailability. Discuss the pharmacokinetic methods for the bioavailability measurement.
[4 marks]Describe the method of residuals for determination of absorption rate constant
[6 marks]Compare and contrast excretion rate method and Sigma-Minus method. Explain Sigma-Minus method in detail
[4 marks]Describe assumption to be considered in developing equation for two compartment model with suitable diagram.
[4 marks]Explain Catenary and Mammillary compartment models in detail.
[6 marks]Write a short note on Plasma Protein Binding.
[4 marks]Enlist the causes for non-linearity. Explain Michaelis Menton Equation for the same. Q. 6 (a) Discuss the regulatory requirements for conduction of bioequivalence study.
[6 marks]What are loading and maintenance dose? How are they calculated
[4 marks]Explain effect of PKa and pH of absorption parameter.
[4 marks]Enlist various mechanism of drug transport. Write a detailed note on active transport process.
[6 marks]Discuss tissue permeability of drug distribution.
[4 marks]Discuss the influence of BBB and CSF barriers on distribution of drugs.
[4 marks]