Pharmaceutical Organic Chemistry III — Winter 2020

State and expalin Recemic mixure and write note on different methods of resolution.

Give the Preparation, Properties and Chemical reaction of Pyrrole.

Give Difference between Enantiomers and Diesteriomers.

Give brief note on Conformation of Cyclohexane.

State and Explain

Enantiomers b) Diesteriomers c) Specific rotation

Mesomers e) Geometric Isomer

Write short note on preparation and chemical properties of Thiazole.

Give Brief note with mechanism on

Dakin Reaction b) Schmidt rearrangement

Comment on following statements

Furan has high boiling point than Pyrrole. ii) Furan is aromatic in nature although it containing two lone pair electron. iii) Thiophene is more aromatic than pyrrole. iv) Electrophilic substitution on pyridine favour at Cposition.3

Pyrrole is more basic than pyridine and aliphatic amine.

Write a Short Note on Geometric Isomerism.

Write the Structure, Reaction, and Medicinal use of Imidazole, Oxazole.

Give any three preparation of i) Indole ii) Quinoline

Give Structure of following ring system

Pyrimidine ii) Isoquinoline iii) Purine iv) Acridine v) Thiazole

Give Brief note with Mechanism on

Clemmensen Reduction b) Beckmanns rearrangement

Complete the reaction H2SO4/HNO3 N N H N H2SO4 N H N NaNH2 S I2 N H

Explain Hantzsch Synthesis in detail with structural mechanism Q. 6 (a) State and Explain and give brief note on Atropisomers with suitable examples.

Write short note on preparation and chemical properties of Pyridine.

State and explain with structural mechanism - Electrophilic substitution reaction favour Cposition in Furan.2

Give brief note on Claisen-Schmidt Condensation and Wolff Kishner Reduction.

Explain in brief with suitable example - Stereospecific and Stereoselective reactions.

Give brief note on reaction involve in LiAlH and NaBH 4 4.