Pharmaceutical Organic Chemistry III — Winter 2023

Give the Preparation, Properties and Chemical reaction of Pyrrole.

Discuss the Sequence rule to assign configuration with example.

Comment on the following 1. Pyridine is more basic than Pyrrole. 2. Pyridine is less basic than aliphatic amines

Write the Structure, Reaction, and Medicinal use of Imidazole, Oxazole.

State and explain Recemic mixure and write note on different methods of resolution.

Give brief note on reaction involve in LiAlH4 and NaBH4

Define following terms. 1) Enantiomers 2) Atropisomers 3) Conformational isomer 4) Diastereoisomer 5) Heterocyclic compound 6) Chirality

Describe Conformational isomerism of Cyclohexane

Explain Clemmensen reduction in detail

Give Brief note with mechanism on

Dakin Reaction b) Schmidt rearrangement

Explain Hantzsch Synthesis in detail with structural

Discuss basicity of pyridine

Explain any two synthesis and medicinal uses of Pyridine

What are Stereospecific and Stereoselective reactions? Explain in detail

Write in detail about Stereochemistry of Biphenyl compounds Q. 6 (a) Draw the structures of azepines and acridine and discuss any two reactions of them.

Comment on following statements

Furan has high boiling point than Pyrrole. ii) Furan is aromatic in nature although it containing two lone pair electron. iii) Thiophene is more aromatic than pyrrole. iv) Electrophilic substitution on pyridine favour at C3 position.

Pyrrole is more basic than aliphatic amine

Discuss nomenclature and classification of thiophene and furan

Give the structure of: (1) Indole (2) Pyridine (3) Isoquinoline (4) Imidazole (5)Acridine (6) Thiophene

Define plane polarized light and discuss optical activity in detail

Draw the structures of quinoline and isoquinoline and discuss any one synthesis of both.