Pharmaceutical Organic Chemistry III — Winter 2022

What do you mean by Racemic modification? Write down different methods of resolution of racemic mixture.

Explain how Pyrrole is both acidic as well as basic.

Give the biological and medicinal significance of Furan derivatives.

Give two methods of synthesis of these followings:

Imidazole ii) Thiophene iii) Furan.

Write down the various reactions of chiral molecules.

Write the chemical preparation and reactions of Pyridine.

Write a short note on Birch Reduction with its mechanism.

Enlist the different methods to determine the configuration of geometrical isomers.

Write a short note on Relative Configuration. Give an example of it.

Discuss the following: i. Fischer Indole synthesis ii. Paal-Knorr synthesis of Pyrrole.

Give detail stereoisomerism of compounds which do not have chiral center.

What do you mean by conformation? Write in detail conformation of butane.

Draw the structure of the followings: 1H- Azepine Acridine 3-imidazoline 1,3- diazine 1,2- oxazole Pyrrolo [2,3-b] indole.

Write a short note on Conformation of cyclohexane.

Describe the various methods to draw an enantiomers with suitable example. Q. 6 (a) Write short note on these followings: i. Chichibabin reaction ii. Skraup synthesis

Write down the various rules of CIP system. Give suitable example of it.

What do you mean by optical activity? Describe the conditions for optical activity.

Write a short note on stereoselective and stereospecific reaction along with example.

Write the chemical Preparation and reactions of Pyrazole.

Describe in detail metal hydride reduction with suitable examples.