What is combinatorial chemistry? Discuss in detail about different methodologies used for synthesis?
[6 marks]Explain Hansch Linear Free Energy Relationship model in drug design?
[5 marks]Explain the Molecular modeling strategies and its applications?
[5 marks]Give the SAR of quinolone antibacterial? Draw the scheme of synthesis of ciprofloxacin?
[6 marks]Write a note on Computer Aided Drug Design?
[5 marks]Give the synthesis of –
[5 marks]Chloramphenicol ii) Sulphacetamide
[ marks]Explain the SAR of sulfonamides? Comments on sulphonamides are not use in presence of pus?
[6 marks]Discuss in detail alkylating agents?
[5 marks]Write a short note on aminoglycoside antibiotics?
[5 marks]Give the method of synthesis & uses of -
[6 marks]Trimethoprim ii) Norfloxacin
[ marks]Classify anti-HIV agents with examples and write a note on protease inhibitors?
[5 marks]Explain the SAR of Tetracyclines?
[5 marks]Define and classify anti-neoplastic agents with examples? Give the synthesis of Tamoxifen?
[6 marks]Discuss on the natural products used as anti-neoplastic agents?
[5 marks]Write a short note on antifungal agents? Q. 6 (a) Define and Classify antimalarial with suitable examples of each class? Give synthesis and mode of action of chloroquine?
[6 marks]Write a short notes on Antiamoebic agents?
[5 marks]Give the synthesis of –
[5 marks]Amandatine ii) Fluorouracil
[ marks]Classify antitubercular agents with examples? Explain the MOA of first line antitubercular agents? Give the scheme of synthesis of ethambutol?
[6 marks]Write the degradation of penicillin with structures?
[5 marks]Write a note on anthelmintics?
[5 marks]