Pharmaceutical Chemistry – IX (Medicinal Chemistry - III) — Summer 2022

Give classification of anticancer agents with at least three drug examples and one structure of each category.

Give SAR of Sulphonamides.

Give structure of the following drugs: (Any five)

. Sulphacetamide ii). Isoniazid iii). Chlorambucil iv). Mebendazole v). Ketoconazole vi). Pyrazinamide.

Give SAR of Cephalosporins.

Give synthesis, IUPAC name and use of Chloramphenicol OR Chloroquine.

Give explanation with diagram or chart on mechanism of action of any three classes of antifungal agents

Give synthesis and use of: (Any three)

. Norfloxacin ii). Clotrimazole iii). Albendazole iv). Pyrimethamine.

What do you know about β-lactam antibiotics? Classify Penicillin with at least two drug examples and one structure of each category.

Share your knowledge on MDR-TB and XDR-TB.

Give SAR of Tetracyclines.

Here several name of drugs have been enlisted. Classify them in the category of antiviral, anticancer, antimalarial, antifungal and anthelmintic agents: Mercaptopurine, Flucytosine, Metrifonate, Gancyclovir, Oxiconazole, Primaquine, Rimantadine, Benzotepa, Artemether, Niridazole.

Discuss in detail Macrolide antibiotics OR aminoglycoside antibiotics.

Give synthesis and use of: (Any three)

. Sulphamethoxazole ii). Ethambutol iii). Amantadine iv). Thiotepa.

Give classification of anthelmintic agents with at least three drug examples and one structure of each category.

What do you know about HIV. Give classification of antiHIV agents with at least three drug examples and one structure of each category. Q. 6 (a) Give an informative note on antiamoebic agents giving synthesis of metronidazole.

Share your knowledge on molecular modeling.

Write a note on lead identification.

Give a detailed note with diagrammatic picture of parallel synthesis.

Give an informative note on Hansch Linear Free Energy Relationship model of QSAR.

Write a short note on CADD.