Pharmaceutical Chemistry – IX (Medicinal Chemistry - III) — Winter 2020

Classify Antibiotics. Explain the SAR of β-Lactam antibiotic.

Explain in detail life cycle of malaria. Give synthesis of Metronidazole.

Give a detailed account of antiamoebic agents.

Write in brief Free Wilson model with its application.

Describe in brief antineoplastic agent. Give synthesis of Tamoxifen & Thiotepa

Give the detail account of QSAR physicochemical parameters.

Give synthesis, therapeutic uses & mechanism action of chloramphenicol.

Write in brief mechanism of action of Macrolide with SAR of Aminoglycosides

Short Note on Computer Aided Drug Design.

Explain molecular modeling with its significance

Classify sulphonamide. Give synthesis of sulphamethoxazole

Describe in brief β-Lactamase inhibitors.

Give a detail account of antifungal agents

Explain in detail SAR of 4-Aminoquinoline & 8-aminoquinoline.

Write synthesis of a) Albendazole b) Clotrimazole Q. 6 (a) Discuss in brief Antiviral agents. Give its mechanism of action with example.

Write a note on SAR of Tetracycline & Cephalosporine

Short note on Hansch linear Free Energy Relationship.

Classify Sulphonamide. Give a SAR of Fluroquinolones.

What is combinatorial synthesis in peptide & solid phase?

Discuss in brief lead optimization.