Pharmaceutical Chemistry – IX (Medicinal Chemistry - III) — Winter 2021

Define antifungal agents. Explain mechanism of action of various classes of antifungal agents.

Give synthesis and IUPAC name of: (Any two)

. Sulphacetamide ii). Isoniazid iii). Clotrimazole

Give SAR on Aminoglycoside antibiotics.

Define and classify anticancer agents with at least three drug names and one structure of each category.

Give SAR on fluoroquinolones.

Write synthesis and IUPAC name of chloramphenicol.

Give synthesis and uses of: (Any three)

. Amantadine ii). Thiotepa iii). Primaquine iv). Chlorambucil

Write in detail degradation of penicillin.

Share your knowledge about antiamoebic agents. Give synthesis of metronidazole

Define and classify antimalarial agents with at least three drug names and one structure of each category.

Write a detailed note on anthelmintic agents. Give synthesis of albendazole.

Write a detailed note on MDR-TB and XDR-TB.

Give SAR on Tetracyclines.

Write a detailed note on antiHIV agents.

Match the followings: (Drug-Heterocyclic ring-Category) A). Drug B). Heterocyclic ring C). Category 1). Sulphamethoxazole a). Benzimidazole i). Antifungal 2). Ketoconazole b). Pyrazine ii). Antimalarial 3). Pyrazinamide c). Furan iii). Anticancer 4). Mebendazole d). Pyrazole iv). Antibacterial 5). Fluorouracil e). Quinazoline v). Antiviral

. Pyrimidine vi). Anthelmintic

. Oxazole vii). Antimycobacterial Q. 6 (a) Write in detail about Hansch Linear Free Energy relationship model of QSAR.

Write a detailed note on computer aided drug design.

Give a note on different lipophilic parameters of QSAR.

Give an informative note on molecular modeling.

Write a detailed note on lead identification

Write a detailed note on parallel synthesis with well labeled diagram.