Give major pathways of drug metabolism. Explain phase-Ireactions in brief.
[6 marks]What do you mean by drug metabolism? Discuss in brief factors affecting drug metabolism.
[5 marks]What do you mean by CYP 450? Give its functions and importance.
[5 marks]Define receptors. Explain occupational theory and induced fit theory of receptors.
[6 marks]Enlist factors affecting drug-receptor interaction. Explain them in brief.
[5 marks]Match the followings: (A-B) (Drug-category) A (Drug) B (Category) 1) Phenytoin A) Antidepressant 2) Amitriptyline B) Opiod analgesic 3) Diclofenac C) Antiepileptic 4) Morphine D) Cholinergic agonist 5) Salbutamol E) NSAIDs F) Adrenergic antagonist
[5 marks]Define parasympathomimetics. Classify them with two examples and one structure of each category.
[6 marks]Give synthesis of: (Any two)
[5 marks]. Neostigmine ii) Dicyclomine iii). Adrenaline
[ marks]Give short note on neuromuscular blocking agents.
[5 marks]Define adrenergic antagonists. Classify them with two examples and one structure of each category.
[6 marks]Give SAR of phenylethanolamines.
[5 marks]Classify following drugs in the category of adrenergic agonists and adrenergic antagonists: Ephedrine, Adrenaline, Atenolol, Noradrenaline, Acebutolol, Isoprenaline, Guanethidine, Prazocin, Naphazoline, Phenoxybenzamine.
[5 marks]Define sedative and hypnotics. Classify them with two examples and one structure of each category.
[6 marks]Give SAR of tricyclic antidepressants.
[5 marks]Give short note on cognition enhancers. Page 1 of Q. 6 (a) Define NSAIDs. Classify them with two examples and one structure of each category.
[6 marks]Give short note on antiparkinson’s agents.
[5 marks]Give synthesis of: (Any two)
[5 marks]. Paracetamol ii). Chlorpromazine iii). Thiopental sodium.
[ marks]Define antiepileptics. Classify them with two examples and one structure of each category.
[6 marks]Give SAR of phenothiazines.
[5 marks]Give synthesis of: (Any two)
[5 marks]. Amphetamine ii). Phenobarbitone iii). Lignocine Page 2 of
[2 marks]