Give structure and use of the following. 1) Amitryptiline 2) Indomethacin 3) Morphine 4) Diclofenac 5) Carbamazepine 6) Mefenamic acid
[ marks]Write structural difference between amphetamine and ephedrine and synthesis of any one.
[5 marks]Why the enzyme Cytochrome called P-450? Explain catalytic reaction cycle involving it.
[5 marks]Explain different theories of receptors.
[6 marks]Explain factors affecting drug metabolism.
[5 marks]Give the synthesis of following drugs:
[5 marks]Procaine (ii) Salbutamol
[ marks]Define and classify cholinergic agents. What are cholinesterase inhibitors? How do they act? Give examples.
[6 marks]Write synthesis of thiopental sodium with mode of action.
[5 marks]What is myasthenia gravis? Write the structures of the drugs used in the treatment of myasthenia gravis.
[5 marks]What are Sedative and Hypnotics. Classify them in detail.
[6 marks]What is Anaesthesia? Write note on General Anaesthetic agents.
[5 marks]Discuss in detail Cognition enhancers.
[5 marks]What is xenobiotics? Describe Phase-Iof Xenobiotic metabolism.
[6 marks]Classify Local Anesthetics in detail.
[5 marks]What do you mean by hallucination ? Write a note on hallucinogens. Q. 6 (a) Define and classify antiepileptic drugs. Discuss SAR of Benzodiazepines.
[6 marks]Write SAR of barbiturates.
[5 marks]Write a detail note on Antiparkinson’s agents.
[5 marks]Classify antidepressants. Describe in detail about MOA, SAR & therapeutic uses of MAO inhibitors.
[6 marks]What is schizophrenia? Explain SAR of Phenothiazine derivatives as CNS depressants.
[5 marks]Discuss drugs used in treatment of gout. Give synthesis of allopurinol.
[5 marks]