What are Antihypertensive agents? Classify them in detail.
[6 marks]Give SAR of cardiac glycosides.
[5 marks]Write synthesis of Carvedilol and Captopril.
[5 marks]Give SAR of dihydropyridines. Give examples of two such drugs.
[6 marks]What is the difference between cardenolides & bufadienolides?
[5 marks]Name the drug which is synthesised by Hantzsch synthesis.
[5 marks]What is the full form of ACE? Give the pathway of ACE inhibition by drugs.
[6 marks]What is flecainide and how it is synthesised?
[5 marks]Define angina. How it can be controlled?
[5 marks]Give SAR of HMGCoA reductase inhibitors.
[6 marks]How bile acid sequestering agents act?
[5 marks]Write synthesis of warfarin. How it acts?
[5 marks]Write a note on thrombolytic agents & plasma expanders. How they act?
[6 marks]What are carbonic anhydrase inhibitors? How they act? Give examples and structure of two drugs.
[5 marks]How Free Wilson Mathematical Model helps in drug design? Q. 6 (a) Define Diuretic agents? Write SAR of thiazide diuretics.
[6 marks]Write synthesis of furosemide and Ethacrinic acid.
[5 marks]Define CADD. Give its importance.
[5 marks]Write a note on anti obesity drugs. How the drugs reduce lipids?
[6 marks]Write a note on Optimization of lead.
[5 marks]Explain in detail combinatorial synthesis & parallel synthesis.
[5 marks]