Define and classify diuretics. Write a note on loop diuretics.
[6 marks]Sketch the important steps in synthesis of (i) Ethacrinic acid (ii) Furosemide.
[5 marks]Explain in detail the steric and electronic parameters used in QSAR.
[5 marks]Write the structure, its ring system, mechanism of action, metabolism and side effects of any one catecholamine depletory used as antihypertensive.
[6 marks]Sketch the important steps in synthesis of (i) Lignocaine (ii) Flecainide.
[5 marks]Write a note on arterial and venous vasodilators.
[5 marks]Define molecular modeling and write a note on application of Computer Aided Drug Design technique.
[6 marks]Outline the SAR of cardiotonics.
[5 marks]Define QSAR and write a note on Hansch Linear Free Energy Relationship model.
[5 marks]Define antihypertensive agents with its classification and write a note on calcium channel blockers.
[6 marks]Sketch the important steps in synthesis of (i) Captopril (ii) Clofibrate.
[5 marks]Explain the SAR of 1, 4-Dihydro pyridines.
[5 marks]What is Free Wilson Mathematical Model? Explain it.
[6 marks]Enlist the centrally acting adrenergic drugs with structures used as antihypertensives.
[5 marks]Enumerate different methods of lead discovery. Write a short note on optimization of lead. Q. 6 (a) Write a note on plasma volume expanders and antiobesity drugs.
[6 marks]What is the mechanism of action and SAR of ACE inhibitors?
[5 marks]Define cardiotonic drugs. Write classification with structures.
[5 marks]Discuss the mechanism of action and SAR of 5-Sulfamoyl benzoic acid derivatives.
[6 marks]Write a note on combinatorial chemistry.
[5 marks]Write in detail giving examples the role of antiplatelet agents.
[5 marks]