Pharmaceutical Chemistry-X (Medicinal Chemistry) — Summer 2018

Write synthesis of warfarin, carvediol, acetazolamide.

Discuss SAR of ACE inhibitors and dihydropyridines

Write a note on antiplatelet agents.

Write synthesis of metoprolol, clofibrate, hydrochlorthiazide.

Define artial tachycardia and artial flutter. Classify antiarrhythmic agents with chemical structures and mechanism of action.

Write a note on plasma expanders.

Write synthesis of lignocaine, hydralazine, glyceryl trinitrate

Discuss SAR of following:

HMG CoA reductase inhibitors. (ii)Thiazide diuretics

Write a note on thrombolytic agents

Discuss cardiotonic agent in detail. Give SAR of cardiac glycoside.

Define hyperlipoproteinemia. Classify anti-hyperlipidemic agents with chemical structures and mechanism of action. Discuss in brief bile acid sequestrants.

Describe antiobesity agents in detail.

Give one name of drug with its chemical structure of following:

Centrally acting antihypertensive agent (ii) ACE inhibitor (iii) Peripheral antiadrenergic agent (iv) Direct vasodilator

Antiarrhythmic agents (Class 1B) (vi) Xanthine diuretic.

Write a note on carbonic anhydrase inhibitor and aldosterone antagonist.

What is angina pectoris ? Classify anti-anginal agents with chemical structures and mechanism of action. 1 | Pa g e Q. 6 (a) Draw chemical structure and give pharmacological category of following drugs(any six):

Furosemide (ii) Flecainide(iii) Methyl dopa(iv)Nicorandil

Nifedipine (vi) Dicoumarol(vii) Triamterene (viii)Mannitol

Enlist methods used in QSAR analysis. Explain hansch model and free wilson mathematical model.

Write a note on optimization of lead.

Define QSAR. Give its advantages and disadvantages. Enlist different parameters used in QSAR. 2 | Pa g e