Write a note on Hansch Linear Free Energy Relationship (LFER) Model in QSAR Studies
[6 marks]Discuss direct and indirect Molecular modeling
[5 marks]Write a note on high throughput screening (HTS)
[5 marks]Give SAR activity of Dihydropyridines and Give the synthesis of Nifidipine
[6 marks]Give synthesis of any two: a) Metformin b) Glipizide c) Carbimazole
[5 marks]Outline SAR activity of 5- Sulfamoyl benzoic acid derivatives
[5 marks]Define and classify diuretics with suitable examples. Discuss Potassium Sparing Diuretics
[6 marks]Write a note anti anginal drugs
[5 marks]Give structure and synthesis of: 1) Clofibrate b) Warfarin
[5 marks]Write a brief note on Physico Chemical Properties affecting drug action
[6 marks]Write mechanism of action, uses, side effect and SAR of ACE Inhibitors
[5 marks]Write a short note on sodium channel blockers as anti hypertensive
[5 marks]Define Atherosclerosis and classify Antihyperlipidemic agents. Give normal value of LDL, HDL, Triglycerides and Total cholesterol levels
[6 marks]Sketch out the process of blood clotting schematically and discuss on the intervention part of anticoagulants
[5 marks]Give structure of: a) spironolactone b) Procainamide c) Hydralazine d) Acetazolamide Q. 6 (a) Define anti arrhythmic drugs. Give a comprehensive account of antiarrythmic agents used as CVS Drugs with one example in each category
[6 marks]What are calcium channel blockers, classify them and give synthesis of of atenolol
[5 marks]Discuss chemistry and SAR of cardiac glycoside
[5 marks]Give brief account of beta blockers as potential antihypertensive agents.
[6 marks]Classify diuretics give mechanism and structure of one drug from each class.
[5 marks]Write a note on anti obesity drugs
[5 marks]