What are the prodrugs ? Explain the strategies used to enhance the permeability and to reduce the toxicity through prodrugs.
[6 marks]Explain the basic model of QSAR given by Hansch and Fujita.
[4 marks]Explain: Hammett constant, Taft’s steric constant.
[4 marks]Write a note on combinatorial chemistry.
[6 marks]Explain in brief: Wilson and Free model of QSAR along with their merits and demerits.
[4 marks]Write a note on molecular docking, as a technique of CADD.
[4 marks]Write the classification of anti-cancer drugs.
[6 marks]Classify sulphonamides and draw their structures.
[4 marks]Why sulphonamide can cause crystalluria ? Explain the ways to reduce these side-effects.
[4 marks]Give a neat and well labelled diagram of life-cycle of malaria along with the site of action of anti-plasmodial drugs.
[6 marks]Write a note on nucleoside reverse transcriptase inhibitors.
[4 marks]Give the synthesis of clotrimazole and chloroquine.
[4 marks]Write a brief note on penicillins.
[6 marks]Classify cephalosporins in brief. Draw structures as when needed.
[4 marks]Write a brief note on calcium channel blockers as anti-arrhythmic agents. . Q. 6 (a) Write a note on classes of diuretics.
[6 marks]Provide a short note HMG CoA reductase inhibitors.
[4 marks]Give a brief note on warfarin.
[4 marks]Classify anti-diabetic drugs.
[6 marks]Provide a short note on drugs acting on secretion of thyroid.
[4 marks]Explain: Dipyridamole worsen the angina-pectoris.
[4 marks]