Define: Chelation, Bioisosterism, Partition coefficient, Ionization, Optical isomerism, Hydrogen bonding
[6 marks]Define Xenobiotics. Give importance of CYP-450 in drug metabolism.
[5 marks]What are Sympathomimetics agents? Classify them with examples.
[5 marks]Enlist different pathways of drug metabolism. Describe any two conjugation reaction in drug metabolism giving specific examples.
[6 marks]Explain: Biosynthesis and catabolism of catecholamine.
[5 marks]Give the synthesis and uses of following drugs: 1) Carbamazepine 2) Dicyclomine HCl
[5 marks]Write a note on parasympatholytic agents.
[6 marks]Give SAR of Benzodiazepines.
[5 marks]What are antipsychotics drugs? Write SAR of phenothiazines.
[5 marks]What are NSAIDs? Classify them with two examples of each class. Write synthesis of one NSAID having one chiral center.
[6 marks]Classify General anesthetics and give synthesis of Halothane.
[5 marks]Give the structures of following drugs: 1) Scopolamine Hydrobromide 4) Oxazepam 2) Paraldehyde 5) Secobarbital 3) Pentazocine
[5 marks]Write a note on Narcotic antagonists with its mechanism.
[6 marks]Explain in details: Factor affecting drug metabolism including stereo chemical aspects.
[5 marks]Give the synthesis and uses of following drugs: 1) Methohexital sodium 2) Methadone HCl
[5 marks]Define Insomnia. Explain mechanism and SAR of Barbiturates.
[6 marks]Explain stages of anesthesia with classification of Inhalation anesthetics.
[5 marks]Write a note on Fluro buterophenones with its mechanism.
[5 marks]Classify anticonvulsants with its mechanism and SAR.
[6 marks]Give SAR of Morphine analogues.
[5 marks]Give the structures of following drugs: 1) Chlorprothixene 4) Glutethmide 2) Clonazepam 5) Carvedilol 3) Valproic acid
[5 marks]