Write all possible routes for the metabolism of norepinephrine.
[6 marks]Explain the structure activity relationship among phenylethanolamine type of adrenergic agonists.
[5 marks]Explain biosynthesis of nor-adrenaline and role of MAO & COMT in its metabolism.
[5 marks]Describe the SAR of adrenergic agonists.
[6 marks]Write synthesis for Phenylephrine and Salbutamol.
[5 marks]Mention the uses for following drugs: i) Clonidine ii) Terbutaline iii) Naphazoline iv) Pseudoephedrine v) Oxymetazoline.
[5 marks]Explain classification of Sympathomimetic agents.
[6 marks]Give SAR of Benzodiazepines.
[5 marks]What are antipsychotics drugs? Write SAR of phenothiazines.
[5 marks]Define: Chelation, Bioisosterism, Partition coefficient, Ionization, Optical isomerism, Hydrogen bonding.
[6 marks]Write a note on narcotic antagonist.
[5 marks]Explain classification of Anticonvulsant drugs.
[5 marks]Define adrenergic blockers. Explain SAR of beta (β)-blockers.
[6 marks]Write a note on solanaceous alkaloids and analogues.
[5 marks]Discuss in brief the development of medicinal chemistry. Q. 6 (a) Explain various Phase-Ireactions involved drug metabolism with suitable examples.
[6 marks]Write a note on non-steroidal anti-inflammatory drugs (NSAIDS).
[5 marks]Classify the antiepileptics with one drug’s structure from each class.
[5 marks]Give structure of a typical cholinergic agonist. Explain the effect of modification at acyloxy group and quaternary ammonium group on the activity of cholinergic agonists.
[6 marks]Classify the general anaesthetics with two drugs’ structures from each class.
[5 marks]Write the chemical class, synthesis and use of dicyclomine hydrochloride.
[5 marks]