Medicinal Chemistry I — Winter 2023

Enumerate Physicochemical properties affecting biological action. Explain how hydrogen bonding & Optical isomerism contribute to biological action of a drug

Explain biosynthesis and catabolism of nor-adrenaline

Describe the SAR of Sympathomimetic agents

Discuss the various factors affecting drug metabolism

Give structure of following drugs i) Dobutamine ii) Terbutaline iii) Naphazoline iv) Pseudoephedrine v) Clonidine

Write a brief note on Beta adrenergic blockers

Discuss about the oxidation reactions of drug metabolism

Give synthesis of (i) Propranolol (ii) Dicyclomine hydrochloride

Write a short note on Cholinesterase inhibitors

Give synthesis and use of (i) Salbutamol (ii) Tolazoline

Explain the SAR of Parasympathomimetic agent

Discuss SAR of Benzodiazepines

Give synthesis and use of (i) Ipratropium bromide (ii) Carbachol

Give structure, use and mechanism of actions (i) Atropine sulphate (ii) Pilocarpine

Give synthesis and use of (i) Ketamine hydrochloride (ii) Neostigmine Q. 6 (a) Discuss the SAR of Phenothiazine

Give structure and uses of (i) Valproic acid (ii) Gabapentin (iii) Haloperidol (iv) Alprazolam (v) Meprobamate

Give synthesis of (i) Ibuprofen (ii) Halothane

(i) Explain the SAR of barbiturates (ii) Give Synthesis of carbamazepine

Write a brief note on Narcotic antagonists

Discuss the SAR of Morphine analogues