Medicinal Chemistry I — Summer 2020

Write all possible routes for the metabolism of norepinephrine.

Write the biosynthesis of norepinephrine with chemical reactions.

Discuss the types of cholinergic receptors with their distribution.

Describe the SAR of adrenergic agonists.

Write a note on indirectly acting sympathomimetics.

Write the synthesis of salbutamol and propranolol.

Discuss in brief the development of medicinal chemistry.

Make an introductory note on phase Iand phase II metabolism.

Discuss the importance of protein binding and hydrogen bonding in producing drug’s biological action.

Classify the antiepileptics with one drug’s structure from each class.

Discuss the structural modifications of 5-phenyl-1,4-benzodiazepin-2-one.

Write the synthesis of any two anticonvulsant drugs.

Define the word ‘opioids’. Write the name and structures of narcotic antagonists.

Write the mechanism of action of NSAIDs. Write the synthesis of any one NSAID from aryl propionic acid class.

Classify the NSAIDs with one drug’s structure from each class. Q. 6 (a) Define neuroleptics. Write the mechanism of action and possible side effects of them.

Describe the structural modification of side chain of phenothiazines.

Classify the general anaesthetics with two drugs’ structures from each class.

Classify the parasympathomimetics with two drugs’ structures from each class.

Write a note on cholinesterase reactivators.

Write the chemical class, synthesis and use of dicyclomine hydrochloride.