Enlist Physio-chemical parameter of drug affecting biological activity and write about Ionization, solubility and partition coefficient.
[6 marks]What are Xenobiotics? How drug metabolized in Phase - Ireaction? Explain with mechanism.
[5 marks]Define Bioisosterism. Classify it and write any 4 application of Bioisosterism.
[5 marks]Give SAR of beta phenyl ethyl amine class.
[6 marks]Explain biosynthesis and catabolism pathway of Acetylcholine.
[5 marks]Write synthetic pathway of following drugs:
[5 marks]Propranolol ii) Tolazoline
[ marks]Discuss Ring Analogues of Phenothiazines.
[6 marks]Discuss SAR of muscarinic antagonist
[5 marks]Write Synthesis of following drugs: i. Carbachol ii. Neostigmine
[5 marks]Explain SAR of Barbiturates.
[6 marks]Explain mechanism of action of anticonvulsant agents.
[5 marks]Write synthesis of following drugs: i. Carbamazepine ii. Ethosuximide
[5 marks]Short note on volatile Inhalation Anesthetics.
[6 marks]Discuss SAR of Morphine analogues
[5 marks]Explain synthetic pathway of following drugs: i. Ketamine HCl ii. Ibuprofen Page 1 of Q. 6 (a) Give classification of Narcotic and non-narcotic analgesics.
[6 marks]Write about Phase – II metabolism and explain glucuronide conjugation and glutathione conjugation.
[5 marks]Give structure and use of (i) Alprazolam (ii) Salbutamol (iii) Clonazepam (iv) Ethosuximide (v) Diclofenac
[5 marks]Classification of antiepileptic or anti-seizure agents or anticonvulsant agents.
[6 marks]Explain following parameter in terms of how it affects biological activity: i. Bioisosterism Optical ii. Geometrical isomerism
[5 marks]Write a note on Fluro buterophenones with its mechanism. Page 2 of
[2 marks]