Discuss the role of hydrogen bonding and solubility in drug’s biological action
[6 marks]Write a brief note on Bioisosterism
[5 marks]Enumerate factors affecting drug metabolism. Explain stereo-chemical aspects
[5 marks]Outline the biosynthesis of catecholamines. Give synthesis of salbutamol
[6 marks]Give a brief account on α-adrenergic blockers
[5 marks]Give structure and use of (i) Clonidine (ii) Labetalol
[5 marks]Explain (i) Metabolism of paracetamol (ii) Glucuronide conjugation
[6 marks]Write in brief about synthetic cholinergic blockers
[5 marks]Give synthesis (i) Neostigmine (ii) Dicyclomine
[5 marks]Write SAR of β-blockers. Give synthesis of Propranolol
[6 marks]Write a short note on cholinesterase inhibitors
[5 marks]Give SAR of Benzodiazepines
[5 marks]Describe SAR of parasympathomimetic agents
[6 marks]Give structure and use of (i) Alprazolam (ii) Valproic acid (iii) Clonazepam (iv) Pentazocine (v) Diclofenac
[5 marks]Classify general anesthetic agents Q. 6 (a) Classify sedative and hypnotics
[6 marks]Give SAR of Morphine analogues
[5 marks]Explain with example (i) Dissociative anesthetic (ii) Cholinesterase reactivators
[5 marks]Give synthesis (i) Phenytoin (ii) Carbamazepine
[6 marks](i) Explain with example- Narcotic antagonists (ii) Give synthesis of Tolazoline
[5 marks]Give synthesis of (i) Halothane (ii) Ibuprofen
[5 marks]