Medicinal Chemistry I — Winter 2021

Classify adrenergic drugs with examples according the receptors they affect. 0

Explain the structure activity relationship among phenylethanolamine type of adrenergicagonists

Explain biosynthesis of nor-adrenaline and role of MAO & COMT in its metabolism

Explain structure activity relationship of beta blockers and give synthesis of propranalol.

Write synthesis for Phenylephrine and Salbutamol

Mention the uses for following drugs- 0

Clonidine ii) Terbutaline iii) Naphazoline iv) Pseudoephedrine v) Oxymetazoline

Give structure of a typical cholinergic agonist. Explain the effect of modification at acyloxy group and quaternary ammonium group on the activity of cholinergic agonists.

Classify synthetic cholinergic blocking agents with examples and uses. Write synthesis of Dicyclomine HCl.

Explain mechanism of action and uses of following drugs-

Homatropine HBr. ii) Pyridostigmine iii) Pralidoxime chloride iv) Pilocarpine v) Atropine sulphate

Answer the following in short (1.5 marks each)

What are sedatives & hypnotics? ii) Give chemical classification of sedatives & hypnotics. iii) What are different types of Barbiturates? iv) Write synthesis of Diazepam.

Explain the Structure Activity Relationship in Barbiturates OR Benzodiazepines.

Classify Anti-psychotic Drugs. Explain the structure activity relationship at Alkyl side chain and basic amino group of phenothiazines.

Answer the following (2 marks each) 0

Give chemical classification of anticonvulsants. ii) Explain mechanism of action of anticonvulsants. iii) Write synthesis of Ethosuximide.

Explain common structural features of anti-convulsant drugs. Write synthesis of Phenytoin and Carbamazepine.

Explain the mechanism of action for Narcotic and Non-Narcotic analgesics. Write structures of Morphine, Methadone HCl and Ibuprofen. Q. 6 (a) Explain various Phase-Ireactions involved drug metabolism with suitable examples.

Describe Partition Coefficient & Optical isomerism and explain how they contribute to biological action of a drug.

Enlist factors affecting drug metabolism and explain any two of them.

Answer the following (2 marks each) 0

Describe the terms ‘General Anesthetics’ and ‘Dissociative Anesthetics’. ii) Write structures of Halothane and Methohexital sodium iii) Define Narcotic Analgesics. What is the source of Morphine?

Give chemical classification of non-steroidal anti-inflammatory agents with examples.

Write mechanism of action and synthesis of Fentanyl citrate and Mefenamic acid.