What are antitubercular agents? Briefly explain antibiotics antitubercular agents.
[6 marks]What is combinatorial chemistry? Discuss in detail about different methodologies used for synthesis?
[5 marks]Explain in brief about synthetic as antifungal agents. Give the synthesis of Miconazole.
[5 marks]Give the SAR of Tetracyclines.
[6 marks]Give the IUPAC name and synthesis of following drugs. i. Chloramphenicol ii. Isoniazide
[5 marks]Explain Hansch Linear Free Energy Relationship model in drug design.
[5 marks]Classify cephalosporin and represent various rings and numbering system of clinically available beta-lactam antibiotic types with examples.
[6 marks]Explain SAR activities of quinolines.
[5 marks]Write a note on Computer Aided Drug Design?
[5 marks]Give any three structures of macrolide antibiotics and explain why erythromycin is unstable in acid media.
[6 marks]Give the synthesis of – 1) Acyclovir 2) Dapsone
[5 marks]Write a note on molecular modeling.
[5 marks]What are β-lactam antibiotics? Why penicillin is not active against penicillinase secreting microbes? Give some examples of penicillinase resistant penicillins.
[6 marks]Write a note on basic concepts and application of prodrugs design.
[5 marks]What is malaria? How it spreads? Classify antimalarial drugs with examples. Q. 6 (a) What are antiviral drugs? Explain mechanism, therapeutics uses and structures of Loviride, Saquinavir and Idoxuridine.
[6 marks]Write chemical name and synthesis of sulfamethoxazole and Tolnafate.
[5 marks]Give the IUPAC name, synthesis and mechanism of Mebendazole an anthelmintic agent.
[5 marks]Explain: Biguanides and dihydro triazines.
[6 marks]What are Aminoglycosides? Discuss their SAR with examples.
[5 marks]Draw the structures of 1. Mefloquine 2. Capreomycin sulphate 3. Ritonavir 4. Methanamine 5. Ivermectin
[5 marks]